Why are MD simulated protein folding times wrong?

نویسنده

  • Dmitry Nerukhdn
چکیده

The question of significant deviations of protein folding times simulated using molecular dynamics from experimental values is investigated. It is shown that in the framework of Markov State Model (MSM) describing the conformational dynamics of peptides and proteins, the folding time is very sensitive to the simulation model parameters, such as forcefield and temperature. Using two peptides as examples, we show that the deviations in the folding times can reach an order of magnitude for modest variations of the molecular model. We, therefore, conclude that the folding rate values obtained in molecular dynamics simulations have to be treated with care.

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عنوان ژورنال:
  • Advances in experimental medicine and biology

دوره 680  شماره 

صفحات  -

تاریخ انتشار 2010